Using Enzyme as a Context Server with Claude Desktop

Enzyme now integrates seamlessly with Claude Desktop through Anthropic’s Model Context Protocol, allowing you to surface relevant notes from your knowledge base directly in your AI conversations. Here’s a quick guide to getting started.

Setup

Install Enzyme to Claude Desktop:

1. Navigate to Claude Desktop Settings > Developer
2. Click Edit Config
3. Replace the existing config with the following:

{
  "mcpServers": {
    "enzyme": {
      "command": "npx",
      "args": [
        "-y",
        "enzyme-mcp@1.1.3"
      ]
    }
  }
}

4. Restart Claude Desktop

You should now see Enzyme running in the Developer settings:

Using Context in Conversations

Try crafting a prompt like this to see Enzyme in action, replacing the tags and folder names with your own:

Grab my latest 30 notes tagged with #reflections and my most recent 10 notes from Readwise/, which should contain highlights from some articles I’ve read recently. What themes do you notice between my personal thoughts and my reading?

Claude will extract the contents from your notes and use them to generate a response. Just a tip: you can also specify rules for working with your knowledge base structure by using Claude Project notes.

What Makes This Powerful

Instead of manually uploading files or copying notes, Enzyme lets you:

• Reference any part of your knowledge base on demand
• Build conversations with deep context from your notes
• Spot connections across different types of content
• Keep your workflow uninterrupted

This is just the beginning of how Enzyme can enhance your knowledge workflows. Try it out and let us know how you’re using it!

Have questions or feedback? Feel free to reach out directly.